Muscle-specific microRNA-206:research status and prospects
Zheng Pan-pan
Yu Xin-kai
Zuo Qun
Li Wan-wan
Song Ya-yun
Abstract：BACKGROUND:Skeletal muscle accounts for 40%of total body weight, but mechanisms of many skeletal muscle injuries and diseases have not been resolved. MicroRNA-206 (miR-206) is a skeletal muscle-specific microRNA, which plays an important role in skeletal muscle development and regeneration.
<br> OBJECTIVE:To analyze the research status of miR-206 in skeletal muscle injuries and diseases.
<br> METHODS:A computer-based search of PubMed was performed for articles about microRNA-206 in skeletal muscle injuries and diseases published from 1992 to 2014 using the keywords of“miR-206, skeletal muscle”. Final y, 57 articles were included in result analysis.
<br> RESULTS AND CONCLUSION:miR-206 can regulate neuromuscular junction recovery after nerve muscle injury. Studies have shown that to control miR-206 levels may be a new method for the treatment of amyotrophic lateral sclerosis and other muscle diseases. miR-206 can promote the differentiation of satel ite cel s in cel culture, and the lack of miR-206 can delay the differentiation of satel ite cel s. miR-206 is also found to promote the regeneration of skeletal muscle. After long-term exercise, the miR-206 level shows an adaptive decrease, but if the exercise is stopped for some time, the miR-206 level can return to its original level. Its mechanism remains to be studied.
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Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 1087-1093 )