Role of estrogen in bone metabolism
Li Hong-liang
Si Jia-wen
Shen Guo-fang
Abstract：BACKGROUND:Postmenopausal osteoporosis is a systemic bone metabolic disorder that is closely associated with a decrease in the level of estrogen.
<br> OBJECTIVE:To review the influence of estrogen on bone metabolism by exploring the role of estrogen in osteoblasts and osteoclasts.
<br> METHODS:A computer-based retrieval of Medline database and CNKI was performed by the first author to search relevant articles addressing the role of estrogen on osteoblasts and osteoclasts using the keywords of“estrogen, osteoporosis, bone metabolism, osteoblasts, osteoclasts, osteogenesis, bone resorption”both in English and Chinese. Total y 216 articles were retrieved, and according to inclusion criteria, and 48 articles were final y retained.
<br> RESULTS AND CONCLUSION:Estrogen deficiency is associated with a gap between bone resorption and formation, characterized by the loss of bone mass and strength that leads to fragility fractures. Estrogen can regulate the levels of osteoblasts and osteoclasts, thereby inhibiting bone resorption, increasing bone formation, and maintaining bone metabolism.
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Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1077-1081 )