Rapid vascularization of bone tissue engineering

Bao Xiao-gang; Xu Guo-hua

doi:10.3969/j.issn.2095-4344.2015.07.015

Abstract：BACKGROUND:The main strategies to build rapid vascularization of bone tissue engineering focuse on cel-scaffold or cytokine-scaffold composite construction which has shed light upon the repair of large segmental bone defects. <br> OBJECTIVE:To clarify the relevant research progress of the vascularization of bone tissue engineering in the view of the three basic elements of tissue engineering, in order to find out new opportunities for rapid vascularization of bone tissue engineering and to provide inspiration in solving clinical y ischemic diseases. <br> METHODS:The first author searched the PubMed, Wanfang and VIP databases for relevant literatures published from 1990 to 2014. The keywords were“bone tissue engineering, vascularization, cytokines, coculture, stem cel s, osteogenesis, angiogenisis, prevascularization, scaffolds”in English and“bone defect, angiogenesis, vascularized bone tissue engineering, scaffold”in Chinese. After screening, 57 articles were included in result analysis. RESULTS AND CONCLUSION:Early vascularization is one of the current bottlenecks of bone tissue engineering development. With the in-depth study of cel ular and molecular mechanism of osteogenesis and angiogenisis during natural bone development and the advanced biological scaffolds, cel-scaffold or cytokine-scaffold strategies for rapid vascularization of bone tissue engineering have achieved important achievements. Signal transduction factors acting as“ligand”of angiogenesis or osteogenesis exists individual differences, so we should pay attention to take advantage of stem cel s which act as a“donor”;while osteogenesis and angiogenesis are like the two wings of a bird, they are born together and support each other and must function hand in hand, only if they develop coordinately can we realize rapid vascularization of bone tissue engineering. Regulating various cel s or cytokines to meet strict spatial patterns and temporal patterns of expression and simulating the physiological state of natural bone are worth exploring to create rapidly vascularized tissue engineered bone.