Effects of connective tissue growth factor on wound healing and scarring

He Ze-liang; Tang Yong; Yao Zong-jiang; Zhang Xuan-fen

doi:10.3969/j.issn.2095-4344.2015.07.011

Abstract：BACKGROUND:The wound healing is the hot topic in the research of surgery. Connective tissue growth factor plays an important role in the regulation of wound healing. <br> OBJECTIVE:To review the current development of connective tissue growth factor in wound healing, and to investigate the mechanism. <br> METHODS:The CNKI database, WANFANG database, VIP database, Springer Link database and PubMed database were retrieved for the related articles with the key words of“CTGF;CCN2;scar;wound healing;regeneration”in English and Chinese, respectively. A total of 37 articles related to the basic study of connective tissue growth factor involved in the regulation of wound healing were included. <br> RESULTS AND CONCLUSION:Connective tissue growth factor has dynamic expression in skin wound healing and scar formation. In the early stage of wound repair, the transient up-regulation of connective tissue growth factor can accelerate the wound healing by promoting the formation of granulation tissue and new blood vessels, while its sustained expression in wound repair and remodeling phases can promote excessive produce of matrixes, col agen deposition and scar contracture, thereby leading to the formation of pathologic scars. Connective tissue growth factors are involved in the skin wound healing, which have broad application prospects in accelerating wound healing and inhibiting scar formation. Connective tissue growth factor as the downstream product of transforming growth factor-β, in addition to its own biological role, can mediate transforming growth factorβcontributing to the proliferation of fibroblasts, promoting fibrosis, induced adhesion and migration, which is one of its mechanisms underlying the effects on wound healing.