Ginsenoside Rg1 effect on proliferation of spinal neurons
Sun Jian-zhong
Liu Xin-wei
Guan Hua-peng
Zhang Peng
Liu Qi
Yang Jun
Guo Qun-feng
Ni Bin
Abstract：BACKGROUND:Different neuroreceptors medicated by different receptors produce their own biological functions. The root cause of spinal cord injury is the death of neurons and the synaptic dysfunction. Ginsenoside Rg1 may play a protective role in neurons.
<br> OBJECTIVE:To verify the nutritional and protective roles of ginsenoside Rg1 in spinal neurons of Sprague-Dawley rats.
<br> METHODS:The spinal neurons were isolated from embryonic rats at a gestation age of 16 days, and fol owing cryopreservation and resuscitation, the cel s were divided into three groups:blank group, ginsenoside Rg1 group and positive control group (phenol solution). MTT method was used to detect the activity of mitochondria and ginsenoside Rg1 effects on the neuronal proliferation.
<br> RESULTS AND CONCLUSION:Compared with the blank group, the cel absorbance value and cel relative activity were both higher in the ginsenoside Rg1 group, indicating that ginsenoside Rg1 can encourage the growth of neurons. When cel s were intervened by ginsenoside Rg1, cel processes grew faster than those in the blank group, indicating ginsenoside Rg1 can protect the neurons, inhibit neuronal apoptosis, and boost the cel vitality.
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Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1003-1007 )