Age difference of estrogen receptor gene polymorphisms in the elderly women with hip osteoporosis

Wang Zeng-rong

doi:10.3969/j.issn.2095-4344.2015.07.002

Abstract：BACKGROUND:Since the age differences exist in gene polymorphism, the incidence of osteoporosis-induced systemic skeletal diseases is varied in different age groups. <br> OBJECTIVE:To investigate the age differences of estrogen receptor gene polymorphisms in the elderly women with hip osteoporosis. <br> METHODS:Seventy-two elderly women with hip osteoporosis were selected as osteoporosis group, and another 72 non-hip osteoporosis elderly women served as controls. There was no significant difference in age and diseases between two groups (P>0.05). Simultaneously, PCR-RFLP at loci of Xba I and Pvu II and bone mineral density were analyzed and tested. <br> RESULTS AND CONCLUSION:The distribution rates of X and XX al eles were significantly higher in the osteoporosis group than the control group (P<0.05). Patients with the XX genotype were significantly older than those with Xx and xx genotypes (P<0.05). Logistic regression linear correlation analysis showed that the age was obviously correlated with the occurrence of hip osteoporosis in patients with XX genotypes (P<0.05). These findings indicate that gene polymorphisms at XX locus of estrogen receptor gene have some influences on the occurrence of hip osteoporosis in elderly women, and there is the age-related distribution difference.