Alveolar bone loss in rat models of diabetic periodontitis

Wang Li-gang; Xu Bin; Dilinuer Aji; Gulinuer Awuti

doi:10.3969/j.issn.2095-4344.2015.05.010

Abstract：BACKGROUND:Body weight, blood sugar, and the change of periodontal tissue in different time period of diabetic periodontitis rats, simple chronic periodontitis rats and normal rats have different influence on the degree of alveolar bone loss. <br> OBJECTIVE:To establish rat models of diabetic periodontitis and chronic periodontitis, and to further clarify diabetes-increased degree of alveolar bone resorption in periodontitis rats <br> METHODS:Fifty-two eight-week-old specific-pathogen-free male Sprague-Dawley rats were randomly divided into diabetic periodontitis group, chronic periodontitis group and normal control group. In the diabetic periodontitis group, rat models of diabetic periodontitis were established by injection of streptozotocin+periodontal ligation. In the chronic periodontitis group, rat models of chronic periodontitis were established by periodontal ligation and constant pressure. In the normal control group, rats were fed normal y. At 1, 2, 3 and 4 weeks after ligation, changes in periodontium of rats of each group were observed. The maxil a alveolar bone specimens were taken. The degree of alveolar bone loss value in rats of each group was observed under a stereomicroscope. <br> RESULTS AND CONCLUSION:At 1, 2, 3 and 4 weeks after ligation with steel wire, the degree of rat alveolar bone loss was as fol ows:diabetic periodontitis group>chronic periodontitis group>normal control group (P<0.05). Results verified that animal models of diabetic periodontitis and chronic periodontitis were successful y established. Diabetes can increase the destruction to periodontal tissue with periodontitis, and increase alveolar bone loss.