Changes in serum calcitonin gene-related peptide levels in animal models of femoral head osteonecrosis
Huang Tao
Kaisaierjiang Aihemaiti
Cui Yong
Abstract：BACKGROUND:Calcitonin gene-related peptide is a peptide secreted from neuropeptides, has multiple important physiological functions, and plays a key role in normal metabolism of bone tissue, bone defect repair and reconstruction.
<br> OBJECTIVE:To observe the changes in the levels of serum calcitonin gene-related peptide of animal models of osteonecrosis of the femoral head.
<br> METHODS:A total of 45 New Zealand white rabbits were randomly divided into three groups:hormone modeling group, liquid nitrogen modeling group and normal control group. At 4, 6, 8, 9 and 10 weeks after model establishment, serum calcitonin gene-related peptide levels were determined. At 9 and 10 weeks, pathological detection was performed.
<br> RESULTS AND CONCLUSION:Clear bone necrosis was visible at 8 weeks. Simultaneously, serum calcitonin gene-related peptide levels were significantly higher in the hormone modeling and liquid nitrogen modeling groups than in the normal control group. These data suggested that osteonecrosis of the femoral head was possibly strongly associated with serum calcitonin gene-related peptide levels.
Keywords：Femur Head NecrosisModelsAnimalCalcitonin Gene-Related Peptide
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 667-673 )