Biocompatibility of barium titanate piezoelectric ceramic coatings

Ma Hui; Xu Guo-qiang; Dilnur Aji; Wei Qin; Kang Wen; Wu Ze-yu; Rufiya Zulati; Alina Abdujilil; Pahirdin Kaisar

doi:10.3969/j.issn.2095-4344

Abstract：BACKGROUND:The research group have used plasma spraying technique to prepare a piezoelectric ceramic coating on the surface of hydroxyapatite, but the biocompatibility of this new material is not clear. <br> OBJECTIVE:To detect the biocompatibility of barium titanate piezoelectric ceramic coatings prepared by plasma spraying technique. <br> METHODS: (1) Hemolysis test: The leaching solution of test samples, saline and distiled water were added into the rabbit anti-clotting, to detect the rate of hemolysis. (2) Short-term systemic toxicity test: Wistar rats were intragastricaly given the leaching solution of test samples and normal saline, to observe the animal body weight changes. (3) Pyrogen test: The leaching solution of test samples and saline were injected into the ear vein of New Zealand rabbits, to observe the changes of animal body temperature. (4) Sensitization test: The guinea pigs were randomly divided into two groups, and respectively given the leaching solution of test samples and complete Freund’s adjuvant (experimental group) as wel as the saline solution and complete Freund’s adjuvant (control group). In accordance with the stimulus and delayed-type hypersensitivity test requirements in GBT16886.10-2005 Part 10, the maximum dose was used for sensitization test. <br> RESULTS AND CONCLUSION:The barium titanate piezoelectric ceramic coatings have no hemolytic effect, non-toxicity, no sensitization, and cannot cause hot, indicating that the biological piezoelectric ceramic coating has good biocompatibility.