Correlation between estrogen receptor gene polymorphism and bone mineral density in elderly women

Wang Zeng-rong

doi:10.3969/j.issn.2095-4344.2015.02.004

Abstract：BACKGROUND:Estrogen receptor α gene polymorphisms is certainly associated with osteoporosis, but there is stil questionable for the study of risk genotypes. OBJECTIVE:To analyze the correlation between estrogen receptor gene polymorphism and bone mineral density in elderly women. METHODS: Totaly 120 healthy elderly women were enroled to extract the whole blood genomic DNA that was digested using Pvu II andXba I, the distribution and frequency of genotypes were analyzed. Meanwhile, dual-energy X-ray absorptiometry measurements of bone mineral density with the femoral neck, greater trochanter and Ward’s triangle and were done. RESULTS AND CONCLUSION:Xba I digested genotypes included the XX in 6 cases, Xx in 78 cases, xx in 36 cases;Pvu II digested genotypes included the PP in 32 cases, Pp in 50 cases, pp in 38 cases. The age, menopause age and body mass index showed no differences among the different genotypes of elderly women (P > 0.05). The bone mineral density values in the trochanter and Ward’s triangle atPvu II digested PP genotype were significantly greater than those at Pp and pp genotypes (P < 0.05); while no significant differences were found in the bone mineral density values at differentXba I digested genotypes in elderly women (P > 0.05). These findings suggest that estrogen receptor gene polymorphism has certain correlation with the bone mineral density in elderly women, P aleles has certain effect to maintain the bone mineral density of the trochanter and Ward’s triangle in elderly women.