Minocycline hydrochloride slow-release antibacterial ointment in the treatment of combined periodontal-endodontic lesions
Wang Miao-yan
Chen Guang-sheng
Zhuang Hai-yan
Abstract：BACKGROUND:The role of minocycline hydrochloride in adjuvant therapy of chronic periodontitis and <br> periodontal abscess has been widely reported, but detailed study of minocycline hydrochloride for combined periodontal-endodontic lesions is rare at present. <br> OBJECTIVE:To investigate the effect of minocycline hydrochloride in the treatment of combined periodontal-endodontic lesions. <br> METHODS:A total of 68 teeth with combined periodontal-endodontic lesions were treated with periodontal mechanical treatment and root canal therapy. According to the patient’s wiling, 68 patients were divided into experimental group (n=24; local injection of minocycline hydrochloride after periodontal mechanical treatment), positive control group (n=24; local injection of iodine glycerol after periodontal mechanical treatment), and <br> negative control group (n=20; no injection after periodontal mechanical treatment). These three groups were reviewed 1 month after periodontal mechanical treatment, and the differences before and after treatment were compared, including periodontal probing depth, attachment loss and gingival bleeding index. <br> RESULTS AND CONCLUSION: Probing depth, attachment loss and gingival bleeding index in three groups were significantly improved after 1 month of periodontal mechanical treatment (P< 0.05); both probing depth and <br> sulcus bleeding index in experimental group and positive control group were better than that of the negative <br> control group (P < 0.05), and probing depth and sulcus bleeding index in experimental group were better than that <br> of positive control group (P < 0.05). Experimental findings indicate that, in the clinical treatment of combined <br> periodontal-endodontic lesions, in addition to periodontal mechanical treatment and root canal therapy, local application of minocycline hydrochloride can effectively reduce the depth of periodontal pocket, improve gingival inflammatory <br> conditions and consolidate curative effect.
Keywords：periodontal diseasesdental pulp diseaseperiodontal attachment loss
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 5525-5529 )