Database construction and data analysis of von Willebrand factor and platelet glycoprotein Ib alpha mutations
Li Na
Li Qu-huan
Wang An-qi
Abstract：BACKGROUND:The interaction between von Wil ebrand Factor(VWF)and platelet surface receptor, platelet glycoprotein Ib alpha (GPIbα), plays a key role in the process of platelet adhesion, spread and aggregation. Currently, the database col ecting VWF mutations is not complete and GPIbαdatabase has not been constructed yet.
<br> OBJECTIVE:The construction of VWF and GPIbαmutation database can help the researchers in this field to find the important mutation information of these two molecules quickly.
<br> METHODS:For constructing VWF and GPIbαmutation database, data were col ected from Uniprot, VWFdb and literatures by keywords search, the dynamics website was designed using MySQL+Apache+PHP combination.
<br> RESULTS AND CONCLUSION:The database contains 341, 13 and 3 920 wild and mutation records of VWF, GPIbα, and A1 domain. The website connecting with backend database is comprised of the background introduction, the pathological pictures and data download page and so on. Especial y, the information of mutations and virtual mutations can be searched and analyzed through search engine with sample and logical strategy. This database wil be greatly beneficial to study VWF and GPIbα. Furthermore, it can offer some new therapeutic approaches to inhibit the binding of VWF and GPIbα, which serve as an attractive drug target in von Wil ebrand Disease.
Keywords：von Wil ebrand diseasesplatelet glycoprotein GPIb-IX complexmutant proteinsdatabasesprotein
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 4599-4604 )