Osteogenic effect of guided bone regeneration in maxillary sinus augmentation

Li Xiang; Zha Guo-qing; Zhu Shuang-xi

doi:10.3969/j.issn.2095-4344.2014.25.015

Abstract：BACKGROUND:The use of bio-membrane guided bone regeneration in maxilary sinus augmentation is a research hotspot in implantology at present. OBJECTIVE:To investigate the osteogenic effect of guided bone regeneration in maxilary sinus augmentation using colagen membranes. METHODS:The first maxilary molars of nine adult female beagle dogs were extracted and ful-thickness flap was reflected bilateraly, then the sinus floors were lifted with simultaneous implantation. Bio-Oss was placed into the new space under the sinus membrane. On the experimental side in each dog, the bio-membrane covered the osteotomy window. On the control side, the flap was sutured directly, and was not covered by bio-membrane. Two animals were sacrificed at 4, 12, and 24 weeks after surgery, respectively. Gross observation, biomechanical testing and histological examinations were performed. RESULTS AND CONCLUSION: In gross view, new bone formation was observed in al maxilary sinuses. The pul-out force increased with time. At week 24, a significant difference in the pul-out force was noted between the two groups (P < 0.05). Histomorphbomatrical analysis showed much more new caluses at the experimental group than the control group at weeks 12 and 24 after surgery (P < 0.05). The bio-membrane guided bone regeneration has a better effect on new bone formation in the sinus augmentation.