Cardiovascular effects of polymethylmethacrylate in percutaneous vertebroplasty

Song Qi-zhi; Li Tao; Feng Cheng-bin; Lin Ya-jun; Hong Hao

doi:10.3969/j.issn.2095-4344.2014.21.017

Abstract：BACKGROUND:The study on polymethylmethacrylate effects on the cardiovascular system during percutaneous vertebroplasty is limited. <br> OBJECTIVE:To estimate the effects of polymethylmethacrylate on the cardiovascular system during percutaneous vertebroplasty. <br> METHODS:From July 2011 to September 2013, a total of 104 patients (167 vertebral bodies) with osteoporotic vertebral compression fractures and without serious cardiovascular related basic diseases were enrol ed in this retrospective study. Mean arterial pressure, heart rate and oxygen saturation were recorded at the fol owing time points:before local anesthesia, before polymethylmethacrylate injection, 0, 3, 5 and 10 minutes after polymethylmethacrylate injection. <br> RESULTS AND CONCLUSION:The mean arterial pressure was decreased after polymethylmethacrylate injection at 0, 5 minutes (P<0.05) and 3 minutes (P<0.01), and returned to the pre-injection level at 10 minutes. At the same time, the heart rate was increased after polymethylmethacrylate injection at 0, 5 minutes (P<0.05) and 3 minutes (P<0.01), and returned to the pre-injection level at 10 minutes. Oxygen saturation was over 95%, which was unchanged before and after polymethylmethacrylate injection. The results indicated that polymethylmethacrylate injection has a transient effect on cardiovascular system during percutaneous vertebroplasty.