Influence of geniposide on collagen II synthesis of cultured chondrocytes in vitro
Tan Yu-lin
Bao Tong-zhu
Liu Qin
Han Yu
Wang Yan-lin
Liu Yang
Zhou Na-xin
Yan Fei
Zhao Long-tao
Abstract：BACKGROUND:Chinese herb Cape Jasmine Fruit can activate the chondrocytes and geniposide is an important component in this herb. <br> OBJECTIVE:To investigate the effect of geniposide on col agen II synthesis in rat chondrocytes cultured in vitro. METHODS:Rat chondrocytes were separated and cultured in vitro. The chondrocytes were then interfered with 25, 50 and 100 mmol/L geniposide. Normal control group was also set. Col agen II mRNA and protein expression was detected with semi-quantitative RT-PCR and western blot analysis, respectively. <br> RESULTS AND CONCLUSION:RT-PCR and western blot analysis results showed that, geniposide at 25, 50 and 100 mmol/L increased the col agen II mRNA and protein expression (P<0.01). Geniposide can promote the synthesis of col agen II in rat chondrocytes cultured in vitro.
Keywords：chondrocytesarthritiscol agencellular structurearticular cartilage
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 3149-3152 )