Clinical observation of cardiac function in patients with acute myocardial infarction complicated with heart failure undergoing stem cell transplantation：a 2-year follow-up visit

Chen Xiao-ming; Yang Zhi-yong; Cui Dan-yang; Zhang Ming

doi:10.3969/j.issn.2095-4344

Abstract：BACKGROUND: Many animal experiments and clinical trials have demonstrated that stem celltransplantation can improve heart function and reduce ventricular dilatation and ventricular remodeling, which has shown an incomparable superiority over traditional therapies in the treatment of myocardial infarction complicated by heart failure. <br> OBJECTIVE: To observe the clinical effects of single autologous peripheral blood stem celltransplantation in acute myocardial infarction patients with heart failure. <br> METHODS:Since 2006 August to 2010 June, 23 patients who were diagnosed to have acute ST elevation myocardial infarction complicated with heart failure were selected and divided into two groups: celltransplantation group (n=11) and control group (n=12). Al patients underwent emergency coronary angiography and percutaneous coronary intervention with drug eluting stent implantation. In the stem celltransplantation group, peripheral blood stem cels positive for CD34 (about 1×108) were colected mobilized by granulocyte colony stimulating factor at 5 days after stent implantation, and then the cels were injected into infarcted vessels using coronary angiography method. Two-year folow-up was performed after celltransplantation to observe the cardiac function and adverse reactions in patients. <br> RESULTS AND CONCLUSION:After 6 months of folow-up, the cardiac function in the celltransplantation group was improved significantly compared with that before celltransplantation (P < 0.05), and the left ventricular ejection fraction was increased by (6.2±0.2)% and the left ventricular end diastolic volume was reduced by (4.7±2.9) mm. However, there was no difference in folow-up results by the end of 1 and 2 years after celltransplantation (P > 0.05), as wel as no adverse reaction occurred. In the control group, after 6 months of folow-up, the left ventricular ejection fraction was reduced by (0.5±0.1)% and the left ventricular end diastolic volume was increased by (0.4±0.3) mm, which were deteriorated year after year. Percutaneous coronary intervention with autologous peripheral blood stem celltransplantation can significantly improve the left ventricular function, reduce left ventricular volume, and delay or prevent left ventricular remodeling in patients with acute myocardial infarction, which is safe and effective. But up to 2 years after celltransplantation, the cardiac function shows no further improvement.