Effects of different concentrations of platelet-rich plasma on tunnel enlargement after anterior cruciate ligament reconstruction
Li Hong-qiu
A Liang
Zhao Zhong-hai
Dong Li-yang
Abstract：BACKGROUND:Platelet-rich plasma contains growth factors that can promote tendon-bone healing, thereby reducing occurrence of bone tunnel enlargement after anterior cruciate ligament reconstruction;different concentrations of platelet-rich plasma have certain influence on bone tunnel enlargement, but it is not clear which concentration is optimal. <br> OBJECTIVE:To study the effect of platelet-rich plasma on tunnel enlargement after anterior cruciate ligament reconstruction. <br> METHODS:Bilateral anterior cruciate ligament reconstruction was conducted in 20 New Zealand white rabbits using Martinek et al’s method. Tendon graft was pretreated with 10 mg platelet-rich plasma gel on one side as an observation group. Graft on the contralateral limb was pretreated with 5 mg platelet-rich plasma gel as control group. At 12 weeks after surgery, radiological observation and measure of the width of bone tunnel were conducted. Tunnel enlargement rate was calculated. <br> RESULTS AND CONCLUSION:At 8 and 12 weeks after anterior cruciate ligament reconstruction, the width of tunnel enlargement was less in the 10 mg-platelet-rich plasma group than that in the 5 mg-platelet-rich plasma group (P<0.05). Bone density of tendon-bone interface was larger in the 10 mg-platelet-rich plasma group than that in the 5 mg-platelet-rich plasma group (P<0.05). These results indicated that platelet-rich plasma promoted in bone density of tendon-bone interface after rabbit anterior cruciate ligament reconstruction, effectively prevented enlargement of bone tunnel. Moreover, 10 mg platelet-rich plasma is perfect.
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Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 8666-8671 )