Synergistic factors of endothelial progenitor cell transplantation in the treatment of diabetic foot

Guo Ji-qiang; Liu Ai-bing

doi:10.3969/j.issn.2095-4344.2013.40.015

Abstract：BACKGROUND:The treatment of diabetic foot has become a“bottleneck”. The transplantation of autologous bone marrow or peripheral blood endothelial progenitor cells is a new way for the treatment of diabetic foot in recent years. <br> OBJECTIVE:To review the effects of vascular endothelial growth factor receptor 2 and the integrin in treatment of diabetes foot by transplantation of endothelial progenitor cells. <br> METHODS:The first author searched PubMed database and Chinese periodical ful-text database for related articles published between January 1998 and December 2012, with"diabetic foot, endothelial progenitor cells, VEGFR-2, integrin, synergistic effect"in English and Chinese, respectively. A total of 98 articles were searched, and 60 were included after excluding repetitive articles. <br> RESULTS AND CONCLUSION:In the diabetic foot treatment, autologous bone marrow or peripheral blood endothelial progenitor cells has around increasing attention, and gradual y become the focus of this field. Therapy with endothelial progenitor cells has gradual y developed into a new method for diabetic foot. Vascular endothelial growth factor receptor 2 and the integrin may exhibit synergistic effects in the treatment of diabetes foot. However, the mechanism remains poorly understood. Further studies are needed to wel understand their mechanism of action.