Anti-aging action of human umbilical cord mesenchymal stem cells combined with lycopene

Li Qian-qian; Cui Xiao-lan; Shi Han; Liu Jia; Cheng Xue; Wang Yi-zhong

doi:10.3969/j.issn.2095-4344.2013.40.004

Abstract：BACKGROUND:Studies have demonstrated the anti-aging action of human umbilical cord mesenchymal stem cells or lycopene. However, there are few researches on the anti-aging action of their combination. <br> OBJECTIVE:To investigate the anti-aging effects of human umbilical cord mesenchymal stem cells combined with lycopene on D-galactose-induced aging model in mice. <br> METHODS:Subactute aging model was established in ICR mice by subcutaneous injection of D-galactose. The experimental mice were divided into control group, model group, stem cellgroup, lycopene and stem cells+lycopene group. The mice were sacrificed after 8 weeks. The activity of superoxide dismutase, the content of malondialdehyde in serum, liver, brain and the content of hydroxyproline in skin were determined. <br> RESULTS AND CONCLUSION:Compared with the control group, the activity of superoxide dismutase and the content of hydroxyproline were significantly reduced, but the content of malondialdehyde significantly increased in model group mice (P ≤ 0.01). Compared with three treatment groups, the activity of superoxide dismutase and the content of hydroxyproline were significantly lower, but the content of malondialdehyde significantly greater in the model group (P ≤0.05). However, there was no statistical significance in content of malondialdehyde between model and lycopene groups (P>0.05). The activity of superoxide dismutase and the content of hydroxyproline were significantly higher, but the content of malondialdehyde significantly lower in stem cells+lycopene group compared with stem cellor lycopene groups (P ≤ 0.05). Results suggested that human umbilical cord mesenchymal stem cells and lycopene have anti-aging effects, and the anti-aging effects of the combination of them are better than either of them.