Retinal stem cell culture supernatant induces differentiation of bone marrow mesenchymal stem cells
Wang Zhuo
Wang Dan
Hao Dong-hai
Li Bo
Abstract：BACKGROUND:Differentiation of bone marrow mesenchymal stem cells into nerve cells has brought a new hope for the repair and regeneration after nervous system injuries.
<br> OBJECTIVE:To study the neuron-like differentiation of bone marrow mesenchymal stem cells induced by the retinal stem cellculture supernatant.
<br> METHODS:The whole bone marrow culture was applied. The differentiation results of bone marrow mesenchymal stem cells induced by retinal stem cellculture supernatants were identified by immunofluorescence method.
<br> RESULTS AND CONCLUSION:After 72 hours of induction, bone marrow mesenchymal stem cells express nestin and microtubule-associated protein 2. Retinal stem cellculture supernatant can promote bone marrow mesenchymal stem cells differentiating into neuron-like cells, suggesting that retinal stem cells may secrete nerve growth factor.
Machine-generated Keywords：
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 7021-7027 )