A membrane controlled release drug delivery system promotes injured tissue repair

Li Wei; Dai Jiang-hua; Luo Jun; Dai Min; Gao Qian-kun

doi:10.3969/j.issn.2095-4344.2013.25.019

Abstract：BACKGROUND: At present many studies have pay attention to the sustained-release and control ed-release effects, as wel as biocompatibility, in membrane control ed release drug delivery system. There are also some studies addressing the mechanisms underlying injured tissue repair with these drug membranes, in which stem cel s are the key factors. However, the association between stem cel s and the sustained and control ed drug release membrane has not yet been paid enough attention. OBJECTIVE: To analyze the current research status and progress of membrane sustained-release system in the repair of tissue injuries. METHODS: Using the keywords of “sustained-release system, membrane, drug delivery, injuries and repairs of tissue, stem cel homing” in Chinese and English, a computer search of PubMed, CNKI, Elsevier databases was performed for articles published from January 1992 to March 2012. Articles related to clinical application and experiment research of sustained-release and control ed-release pharmaceutical polymer materials were included. RESULTS AND CONCLUSION: In the membrane sustained-release system, polymer materials have almost become the critical part of drugs and growth factors in the process of infiltration and penetration. Although drug delivery system and membrane preparation technology are constantly updated, it is not enough to achieve the desired application standards, such as do not have the initiative to attract direct migration and distribution of stem cel s. In recent years, there is a new development trend for membrane sustained-release system, which not only can induce stem cel s homing to injury sites, but also can promote the differentiation and distribution of stem cel s, thereby promoting the renovation of tissue injury.