Bone osseointegration of various acetabular surfaces in weight bearing
Zhao Jian-fei
Lu Meng
Victor L.Fornasier
Abstract：BACKGROUND: In order to enhance the rate and degree of osseointegration of cementless implants, hydroxyapatile(HA) was applied on the different prosthesis surfaces. The majorities of these studies have utilized non-weight-bearing in vivo dog models and have focused on the fixation of the femoral component. What is the osseointegration of macrotextured acetabular components in a weight-bearing model(dog) like?OBJECTIVE: To evaluate the various macrotextured surface coatings applied to acetabular components of the same design in aweight-bearing canine total hip replacement model.DESIGN: Randomized conparative study using theexperimentalanimals as subjectsSETTING: Department of Ortopaedics, Beijing Tongren Hospital;PathologyDepartment, Bone and Joint Laboratory, St. Michael' s Hospital, U of T,Toronto,CanadaMATERIALS: The experiment was completed in the Pathology Department,Bone and Joint laboratory, St. Michael' s Hospital, U of T, Toronto, Canada from October 2001 to December 2001. Acetabular components with the selected surface characteristics were implanted into forty dogs with the body mass of 29 - 44 kg of either gender and divided into seven groups, including group 1 (AD/HA), Group 2 (CoCr beads/PA), Group 3 (CPTi bead surface), Group 4 (CPTi 30 PPI foam), Group 5(CPTi 30 PPI/PA foam),Group 6(CPTi 40 PPI foam), Group 7(CPTi 40 PPI/PA foam).METHODS: Exercise was restricted to leash walks for the first fourteen days post-operatively. After this, dogs were allowed unrestricted activity. The dogs were euthanized at either three or sixmonths after surgery as the project' s protocol. The whole acetabulum, divided into weight-bearing and non weightbearing areas, containing the component was harvested and submitted for histological and histomorphological assessment.
MAIN OUTCOME MEASURES: The bone ongrowth and ingrowth with weight bearing and without weight bearing areas in each group.RESULTS: There was significantly greater bone apposition and bone ingrowth for implants with HA coatings ascompared to uncoated implants. There was also significantly greater bone ingrowth in weight-bearing areas as compared tonon weight-bearing areas at both time periods. The bone growth into AD/HA was 17％ at 3 months and descended to 14％ at 6 months. The bone growth into CPTi beads surface was 21％ at 3 months,30％ at 6months in weight-bearing areas. All four foam-coating surfaces there were 15％ to 21％ ongrowth at 3 months, 15％ to 32％ at 6 months and 21％ to 32％ ingrowth at 3 months, 29％ to 45％ at 6 months in weight-bearing areas( P ＜ 0.05).CONCLUSION: Hydroxyapatite coating produces significantly greater boneingrowth and apposition in all the surface treatments tested in this study. Weight bearing produces a greater bone ingrowth than non weight-bearing areas and obviously increases with the time prolonging, especially the foam coating
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Publication Date：2005-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 182-185 )