Value of multitude evoked potentials for early diagnosis of Parkinson disease

doi:10.3321/j.issn:1673-8225.2004.31.020

Abstract：BACKGROUND:Neuroelectrophysiological observation on Parkinson disease is performed, but there is not any neuroelectrophysiology index which can afford a sensitive and accurate diagnosis of early Parkinson disease.OBJECTIVE: To observe the abnormal characteristics of somatosensory evoked potentials(SL-SEP), brain stem auditory evoked potentials(BAEP)and pattern reversal visual evoked potentials(PR-VEP) in early stages of Parkinson disease, and find sensitive and reliable diagnosis index.DESIGN: Case-control trial based on diagnosis.SETTING and PARTICIPANTS: A total of 52 inpatients with Parkinson disease, whose Yahr stage was Class I, were selected from the Department of Neurology and Outpatient,the Affiliated Union Hospital of Fujian Medical University, and 40 health volunteers were selected as control group. All patients were observed with three kinds of evoked potentials.INTERVENTIONS: All patients in case group andcontrol group were tested with SL-SEP, BAEP and PR-VEP.MAIN OUTCOME MEASURES: Peak latency(PL), inter peak latency(IPL) and amplitude of dominant wave of SL-SEP; Ⅰ, Ⅲ, VPL, Ⅰ-Ⅲ IPL,Ⅲ -ⅤIPL, ratio of Ⅰ-ⅢIPL/Ⅲ-Ⅴ IPL of BAEP; P100 PL of PR-VEP.RESULTS: The abnormal rate of SL-SEP, BAEP and PR-VEP were 69.2%, 32.7% and 30. 7% in early stages of Parkinson disease respectively. The PL and IPL of dominant wave of SL-SEP in case group were significantly different from those in control group( P < 0. 01 ) . The amplitudes of P25(2.4 ± 1.9) μV and N30(1.5 ± 1.5) μV of SL-SEP in case group were significantly different from those [ (3.4 ±2.3) μV, (2.4 ± 1.1) μV] in control group( P < 0.01). The amplitudes of N20(2.5 ± 1.0) μV and P22(2. 3 ± 1.4) μV of SL-SEP in case group were not significantly different from those[(2.7±1. 1) μV,(1.7±1.3) μV] incontrol group(P> 》 0.05) Ⅰ-ⅢIPL,Ⅲ - Ⅴ IPL and the ratio of Ⅰ- Ⅲ / Ⅲ- Ⅴ of BAEP in case group were (2.27±0.33) ms, (1.96±0.24) ms and(0.88±0.13) respectively,which were not significantly different from those (2.21 ±0. 16) ms, (1.89 ± 0. 18) ms and (0. 86 ± 0. 10) respectively in control group ( P > 0. 05).P100PL of PR-VEP(97.85 ± 11.6) ms in case group was not significantly different from that (95.13 ± 5.16) ms in control group( P> 0.05).CONCLUSION: The treating process of cortical sensation is interfered in the early stage of Parkinson disease. The pre-central component and parietal component P25 of SL-SEP is a sensitivelydiagnostic index.