Analysis of calcium polyphosphate/poly (L-lactic acid) cartilage-tissue engineering scaffold composite
Abstract：BACKGROUND: Although fibriform and spongy scaffold made of degradable macromolecular materials like poly(L-lactic acid) (PLLA) and polyglycolic acid(PGA) has been greatly used , its shortcomings are obvious, such as low elastic modulus, deformable by force, inducing implanted cell injury,and delayed degradation speed.OBJECTIVE: To find a calcium polyphosphate (CPP) fiber with controllable degradation speed, good mechanical characteristic, biocompatibility and toxicological characteristic and to make cartilage tissue engineering composite with this fiber as enhancing agent.DESIGN: Different mass proportion grouped and controlled experiment was conducted.SETTING and PARTICIPANTS: The experiment was conducted in the Institute of Materials Engineering, Lanzhou Jiaotong University. The basic materials were PLLA(from Department of Polymer Synthesis, Institute of Chemistry, Chinese Academy of Sciences) and the enhancing material of CPP made by the authors.INTERVENTIONS: To make CPP/PLLA cartilage tissue engineering scaffold from PLLA as basic material and CPP as enhancing agent which has high strength and modulus, and predisposed degradation speed as well. The method adopted was solvent adding and granule extraction. The scaffold mechanics characteristic and in vitro biodegradation in Hank' s solution at 37 ℃ were tested.MAIN OUTCOME MEASURES: Mechanical characteristic and degradation characteristic.RESULTS: Microstructure of PLLA composite was full of 3 dimensionally interconnected microsopical net feature with evenly distributed micropores,whose size was 130-350 μm and aperture ratio of 90%. Its compression modulus and degradation speed increased as the CPP fiber fraction increased.
Keywords：The biological characteristics of extracorporeally fabricated CPP/PLLA scaffold composite could meet the mechanics and degradation demand of tissue-engineered cartilagewhich means it can be used as scaffold for tissue-engineered cartilage
Publication Date：2004-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 3373-3375 )