Combined renovation of bone defects with bone matrix gelatin,autologous red bone marrow and homograft bones
Abstract：BACKGROUND: Boue matrix gelatin(BMG), autologous red bone marrow (RBM) and homograft bones are often used to repair bone defects, but the study of curative effects of combined renovation of bone defects with the three materials is rare.OBJECTIVE: To evaluate the curative effects of combined renovation of bone defects with BMG, autologous RBM and homograft bones.DESIGN: A follow-up survey study of cases depended on diagnosis was conducted.SETTING and PARTICIPANTS: The study was completed in the Department of Orthopaedics, Tongji Hospital, Tongji Medical Collage of Huazhong University of Science and Technology. The subjects were patients with benign bone tumors and tuberculate damage treated in the hospital from October,1999 to February, 2002. 49 males and 27 females, aged 14-36 years old without any other diseases.INTERVENTIONS: In 76 patients with benign bone tumors and tuberculate damage, thorough curettage of foci or bone segment removal of tumors was conducted. Tumor walls were inactivated. Homograft bones were used as support and around which BMG and autologous RBM were filled.MAIN OUTCOME MEASURES: Organism reactions and renovation of bone defects after operation.RESULTS: Time of follow-up surveys of all the cases was 5-16months. Tine of new bone formation showed by X-ray was 1.5-4 months and complete ossification was 5-9 months after operations. Totally 74 cases reached bony union and obtained preferable joint function. Tumor recurrence: 2 cases. There was no immunologic rejection after operation.CONCLUSION: The combination of BMG, autologous RBM and homograft bones can effectively renovate bone defects and has a widespread prospect in clinical application.
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Publication Date：2004-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 2742-2743 )