Differentiate activation of MAPK conductive gateway in hippocampus damages induced by microwave irradiation in rat
Abstract：AIM: To discuss the effects of microwave irradiation on the neurocyte mitrogen-activated protein kinases(MAPK) signal conductive system in hippocampus nerve and the reaction of MAPK conductive gateway in hippocampus neural damages.METHODS: Anti-phosphorylation extracellular synal-regualted kinase (ERK1/2), C-Jun N-terminal kinase(JNK) and P38 MAPK antibody were introduced in Western blot process to dynamically observe the phosphorylation changes of rat hippocampus neurocyte protein ERK, JNK/SAPK and P38 MAPK in order to reflect the functional status of MAPK signal gateway after microwave irradiation.RESULTS: Within 12 hours after microwave irradiation, ERK and JNK were continuously activated, the peak of ERK appeared immediately after irradiation, and JNK peak appeared after 3 hours of irradiation. And after 24 hours,both activations were inhibited; P38 MAPK was continuously in activating status within 24 hours after irradiation, and there were 2 activating peak appeared at 3 and 24 hours after irradiation.CONCLUSION: Microwave irradiation can induce differentiate activation in three MAPK signal conductive gateways of neurocyte of hippocampus and moreover, the hippocampus damages induced by microwave irradiation might be achieved through the differentiate activation of MAPK signal conductive gateway.
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Publication Date：2004-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 772-773 )