Observation on therapeutic effect of sophoricoside capsule for postmenopausal osteoporosis
Abstract：AIM:To observe the therapeutic effect of Sophoricoside Capsules on postmenopausal osteoporosis. METHODS:Twenty two-postmenopausal osteoporosis patients with low density of L1- 4 were administered Sophoricoside Capsules,60 mg per day for 3 months.Before and after treatment,the density of lumbar vertebrae and forearm,the serous estradiol,testosterone,follicle stimulating hormone(FSH),Osteocalcin,procollagen type I C-terminal peptide(PICP),and deoxypyridinoline(Dpyr) were tested to observe the rest pain and motion pain of the lower back. RESULTS:There was a big difference in the density of lumbar vertebrae of postmenopausal osteoporosis patients treated with the Sophoricoside Capsule.[L1:(0.769± 0.206)g/cm2 ,(0.816± 0.212) g/cm2,t=- 2.855, P=0.009; L3:(0.915± 0.188) g/cm2,(0.958± 0.205) g/cm2,t=- 2.137, P =0.044; L2- 4: (0.889± 0.197) g/cm2,(0.92± 0.204) g/cm2, t=- 2.256, P=0.035]; testosterone[(0.283± 0.131) ng/ml,( 0.236± 0.133) ng/mL] and FSH[(52.988± 23.113) mIU/mL, (44.225± 18.144) mIU/mL] decreased remarkably(t=2.9864, P=0.007; t=2.624, P=0.016); Dpyr reduced obviously( t=3.856, P=0.001); and the rest pain and motion pain of lower back were relieved markedly after the treatment(rest pain:t=9.566, P=0.001; motion pain:t=6.797, P=0.001). CONCLUSION: The Sophoricoside Capsule improves the density of lumbar vertebrae, inhibits the bone absorption, and noticeably alleviated the lumbar pain greatly.
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Publication Date：2003-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 4122-4123 )