Combined cognitive therapy with fluoxetine hydrochloride on patients with senile depressive neurosis in open wards:A randomized controlled study

doi:10.3321/j.issn:1673-8225.2003.30.010

Abstract：AIM: To observe the effect of a combined cognitive therapy with fluoxetine hydrochloride on patients with senile depressive neurosis in open wards. METHODS:A total of 70 patients met the criterion of senile depressive neurosis described in CCMD-2-R were randomly divided into combined therapy group and control group.Each group consisted of 35 patients,the subjects of combined therapy group received 20mg fluoxetine hydrochloride combined with individual cognitive therapy daily;while the subjects of control group received 20mg fluoxetine hydrochloride daily alone.The effect of the two groups is evaluated with BDI and HAMD four times:before the treatment,2,4 and 8 weeks(the end of treatment) while under treatment.The effect of the two groups is evaluated with SCL-90 before and after the treatment,6 and 12 months after the treatment. RESULTS: Two weeks after treatment in hospital,the scores of the united group on BDI and HAMD were 13.8± 2.6, 20.8± 3.1 respectively,both were significantly lower than those of the control group,which were 16.8± 4.2,26.8± 4.2 respectively (t=3.527,6.667,P< 0.01).At the end of the positive treatment(8 weeks after admission to hospital),the scores of the united group on BDI and HAMD were 6.0± 3.8 and 5.4± 2.8 respectively,both were significantly lower than those of the control group,( t=2.890,3.328, P< 0.01) .4 weeks after admission to hospital,there was no great difference between the two groups in the scores on the two scales(P >0.05).At the end of positive treatment(8 weeks),in the 0.5 year follow up,the scores of the relative factors of somatization,anxiety and depression of SCL-90 were significantly lower than those of the pre treatment in both group( t=2.608- 5.185,P< 0.05- 0.01) .In the control group, the scores of relative factors of somatization,anxiety and depression were not significantly different from those of the pre treatment. CONCLUSION:A combined cognitive therapy with fluoxetine hydrochloride on patients with senile depressive neurosis results in quite a good effect in the near and far future, with the prevention of recurrence.