Effects of electro-acupuncture on Fos protein expression in the hippocampus of rat ischemia-reperfusion model
Abstract：AIM:To access the effects of electro-acupuncture on the expression of Fos protein in rat hippocampus after cerebral ischemia-reperfusion injury. METHODS:Eighteen SD rats were randomly divided into control,model and treatment groups.Bilateral carotid artery occlusion was performed in establishing reperfusion model of focal cerebral ischemia in the latter 2 groups,and electro-acupuncture was administered in the treatment group at the acupoints of " Paihui" ," Fengch" ih," Tachung" and " Tsusanli" at a frequency of 2-20 Hz and the intensity of 2.0 A for 30 minutes.After 4 hours,the expression of Fos protein in rat hippocampus was observed. RESULTS:Electro-acupuncture obviously elevated Fos expression in the hippocampal regions after reperfusion following cerebral ischemia.In the treatment group,Fos-positive cells of all hippocampal regions were significantly increased in comparison with the model group(CA1:236± 26 vs 126± 19,P< 0.05;CA3:328± 80 vs 212± 55,P< 0.05;CA4:594± 104 vs 381± 92,P< 0.01; DG:621± 111 vs 341± 89,P< 0.01). CONCLUSION: Reperfusion after cerebral ischemia in the hippocampus can obviously induce Fos expression that can be strengthened by electro-acupuncture.
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Publication Date：2003-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 3804-3805 )