Protective effects of Naoshuankang against cerebral function deterioration induced by D-galactose in mice

doi:10.3321/j.issn:1673-8225.2003.25.009

Abstract：AIM:To study the protective effects of Naoshuankang (NSK) against the cerebral function deterioration in mice induced by D galactose. METHODS:A total of 96 ICR mice were randomly divided into blank control group,model group,Taponing group,and 3 NSK groups with varied NSK doses (25,50 and 100 mg/kg respectively).The model of deteriorated cerebral function was induced by daily subcutaneous injection of D galactose (120 mg/kg) in the mice, and the learning and memory abilities were assessed by water maze test.The protective effects of NSK against the cerebral function deterioration were observed by investigating the changes in learning and memory abilities, cerebral SOD and GSH Px activities, and the levels of MDA and lipofuscin. RESULTS:All three NSK doses could improve the learning and memory abilities to different degrees, with the time of the mice with NSK treatment at 25, 50, 100 mg/kg and of those in model groups to arrive at point B being (43±18),(54±29),(59±61),(63±26) s, respectively,(t=2.525-2.731,P< 0.05).For assessment of the memory ability, the time recorded for the mice in NSK(25 mg/kg) and model groups was (25±26),(50±35) s, respectively (t=2.525-2.731,P<0.05).NSK at the 3 doses could markedly enhance cerebral SOD and GSH Px activities, and decrease the levels of MDA and lipofuscin (t=-2.675- 2.712,P< 0.05,t=- 8.806- 15.989,P<0.01). CONCLUSION:Inhibition of cerebral lipid peroxidation and increase of cerebral anti lipid peroxidation ability may be one of the mechanisms for NSK to ameliorate abnormal behavior in patients and relieve senile dementia.