Significance of the biological characteristics of transitional mucosa adjacent to rectal cancer for patient prognosis
Abstract：AIM:To study the pathological characteristics of the transitional mucosa (TM) adjacent to rectal carcinoma and their significance in prognostic assessment of the patients. METHODS: Immunohistochemical and mucin histochemical methods were employed to observe the expression of PCNA and the changes in the TM adjacent to the carcinoma in 81 cases of rectal carcinoma. RESULTS: PCNA expression was the highest in the cancer foci and gradually decreased in atypical dysplasia, TM and normal mucosa (F=8.92, P< 0.01). The distribution of TM adjacent to the mucinous adenocarcinoma was more extensive than that to the papilla adenocarcinoma and tubular adenocarcinoma (t=3.15- 3.41, P< 0.01), and the TM adjacent to the rectal carcinoma in Dukes C stage was more extensive than that in stages A and B (t=2.51- 3.10, P< 0.01, P< 0.05). CONCLUSION: The TM around rectal carcinoma possesses certain potential of malignant development, the distribution of which is closely related to the pathological type and progression of the malignancy, therefore facilitating the evaluation of patient prognosis.
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Publication Date：2003-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 3208-3209 )