Effects of Halofuginone contained in traditional Chinese herb of antifebrile dichroa root on wound healing and cicatrisation
Abstract：AIM: To investigate the effects of wound healing and specific inhibition of halofuginone on type-I collagen synthesis. METHODS:Sixty rats were divided into 3 groups:orally taking halofuginone group (group A), locally using halofuginone group (group B) and control group (group C) . The wound was made on the dorsum of the rats and agents applied on it respectively. The residual wound surface area was measured and granulation tissue harvested to take the histological observation and the content of PCⅠ and PCⅢ were detected at 3rd,7th and 14th day postoperatively.The skin strength against tearing was obtained after wound healing. RESULTS:The amount of PCⅠ was increased much lower in group A and B than that in control group while the wound healing speed slowed down and micro-vessels in wound granulation tissue was decreased markedly in group A and B, and subsequently, the skin strength against tearing was reduced significantly in group A and B. CONCLUSION:As a specific type-I collagen synthesis inhibitor, halofuginone should be a good regulator on wound healing and a novel ,satisfactory agent for treating and preventing scarring.
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Publication Date：2003-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 3196-3197 )