Effects of Zhitangshu on insulin resistance in rats with type 2 diabetes mellitus
Abstract：AIM:To observe the improving the effects of Zhitangshu(ZTS) in improving insulin resistance in rats with type 2 diabetes mellitus . METHODS:The diabetic rats models were established by streptozotocin(STZ) injection,which were treated respectively with ZTS,metformin hydrochloride tablets(MHT)and gliclazid tablets(GCT) for 9 weeks .The glucose tolerance and the contents of insulin,glucose,triacylglycerol(TG),non-esterified fatty acid(NEFA), total cholesterol(TC),low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol(HDL-c) of the rats were detected,the total body and fatty tissues of rats were weighed respectively, and the insulin resistance index(IRI) was measured . RESULTS:The effects of ZTS to inhibit the increase of total body and fatty tissue and to lower NEFA, LDL-c and IRI were better than GCT (P< 0.01 orP< 0.001),showing also better effect to reduce NEFA and TC than MHT(P< 0.05), but its effects on the rest indexes including IRI-lowering IRI effect were similar to MHT(P > 0.05).ZTS showed a dose-dependent effect in lowering IRI. CONCLUSION:ZTS has obvious effect to improve insulin resistance in rats with type 2 diabetes mellitus.
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Publication Date：2003-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 2914-2915 )