Alterations neuropeptide Y activity in brain tissue of rats during cerebral hemorrhage and its significance
Abstract：Aim To observe dynamic changes of neuropeptide(NPY) level in periphery of hematoma,hypothalamus and brain stem of rats during cerebral hemorrhage and its significance.Methods Rat model of cerebral hemorrhage was established by combined injection of collagenase and hepatin into caudate nucleus and NPY activities in periphery of hematoma,hypothalamus and brain stem of rats before and at 30 minutes,6,12,24,48 and 72 h after hemorrhage were detected.Radioimmunity was used for detection of NPY activities.Results NPY activities in periphery of hematoma,hypothalamus and brain stem of rats increased sychronously each other,reached the peak at 24 h[(4.37± 0.14),(9.06± 0.15),(7.22± 0.26)μ g/g] and began decreasing from 48 to 72 h.But they were still significantly higher than that before hemorrhage( t=31.321 6,12.571 5,11.648 7,P< 0.01) .Conclusion During cerebral hemorrhage,NPY activity in brain tissue increases.
Keywords：cerebral hemorrhageneuropeptide Yhypothalamusbrain stem
Publication Date：2003-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 2664-2665 )