Change of ultrastructure and aggregation of erythrocyte in patients with essential hypertension and its correlation with blood pressure
Abstract：Aim To observe the changes of ultrastructure and aggregation of erythrocyte in essential hypertension (EH) by electron microscope and to investigate the role of erythrocyte in the process of EH episode. Methods Venous blood specimens of 12 healthy subjects, 6 males and 6 females with the average age of(53± 8)years, and 36 hypertension patients without other diseases, 20 males and 16 females with the average age of(58± 8)years, were prepared and examined by scanning electronic microscope(SEM) and transmission electronic microscope (TEM).Erythrocyte specific surface was measured by quadratic test grid.Results Under SEM and TEM, the percentages of abnormal erythrocytes in EH patients increased significantly (P< 0.05,t=5.11,4.83,3.07,2.98), which had a positive correlation with diastolic blood pressure. The erythrocyte specific surface area of the hypertensive group was smaller than that of the control group (P< 0.05,t=2.56). There was an increase in erythrocyte aggregation in the hypertensive group by TEM and SEM, especially in 9 cases with left ventricular hypertrophy.Conclusion The increase of blood pressure may be related to the change of erythrocyte ultrastructure .The increase of erythrocyte aggregation and decrease of erythrocyte deformability result in the change of hemorheology.
Keywords：hypertensionerythrocytesmicroscopyelectronhemorhedogy
Publication Date：2003-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 2524-2525 )