Influence of dyslipidemia on early renal functional lesions in patients with metabolic syndrome

doi:10.3321/j.issn:1673-8225.2003.18.008

Abstract：Aim To explore the influence of dyslipidemia on early renal functional lesions in patients with metabolic syndrome(MS).Methods 109 cases with essential hypertension (56 males and 53 females, EH group), 73 cases with diabetes mellitus (39 males and 34 females, DM group) and 175 cases with metabolic syndrome (87 males and 88 females, MS group) were respectively divided into two subgroups: normal lipid groups and dyslipidemia groups according to the serum total cholesterol(TC), triglycerides(TG), low density lipoprotein(LDL), and apolipoprotein B(Apo B) levels. The changes of renal function were observed and comparde between the subgroups of normal and dyslipidemia respectively.Results In the MS group, the concentration of microalbuminuria(MA) in the dyslipidemia group was(66± 3) mg within 24 hours, significantly higher than that of the normal group [(45± 4)mg,t=- 3.904,P< 0.01]; the endogenous creatinine clearance rate (Ccr) was (57± 3) mL/min in the dyslipidemia group, significantly lower than that in the normal group[(72± 4)mL/min,t=- 3.838,P< 0.01].But in the DM and EH groups,the concentrations of MA and Ccr were insignificantly different between the normal and dyslipidemia groups respectively. The correlation analysis showed that TC, LDL and ApoB only in the MS group were significantly related with MA and Ccr, and the TC played a most important role in MA and Ccr(r=0.3807, P< 0.01; r=0.3807, P< 0.05).Conclusion Dyslipidemia is one of the important factors inducing renal dysfunction in patients with MS when blood pressure and glucose are controlled at the same levels. Thus, serum lipid lowering therapy may be necessary to prevent deterioration of renal function in patients with metabolic syndrome.