Non-invasive investigation on endothelium-dependent and endothelium-independent dilation of peripheral arterial occlusive disease in the elderly
Abstract：Aim To evaluate the endothelium-dependent dilation(i.e. flow-mediated dilation,FMD)and endothelium-independent dilation( i.e.nitroglycerin-mediated dilation,NMD) of peripheral arterial occlusive disease (PAOD)in the elderly and to investigate the relative factors associated with FMD and NMD respectively.Methods Both FMD and NMD of the brachial artery in 33 old PAOD patients were detected by the color Doppler ultrasonograph and compared with 40 old healthly controls and 30 old non-PAOD patients with cardiovascular risk factors respectively.Results ① Both FMD and NMD of the brachial artery in 33 old PAOD patients were less than those of 40 old healthly controls and 30 old non-PAOD patients with cardiovascular risk factors significantly( t=- 2.2358- 2.7317, P< 0.01) . ② The basic vascular diameter,systolic blood pressure and the blood concentration of LDL-C related with brachial FMD negatively .③ FMD related with NMD positively,but the basic vascular diameter had negative relationship with NMD.Conclusion Both FMD and NMD of the old PAOD patients were impaired . The basic vascular diameter,systolic blood pressure and the concentration of LDL-C may be independent predictors of brachial FMD.
Keywords：agedendotheliumvasodilationarteriosclerosis obliterans
Publication Date：2003-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 2528-2529 )