The basic study of nerves of skin associated with viscera

doi:10.3321/j.issn:1673-8225.2003.17.015

Abstract：Aim To study the distribution regulation of primary neurons and sympathetic neurons of skin associated with viscera on the theoretical basis of treating visceral pain by intracutaneous- injection drug.Methods By intravenously injecting Evans Blue dye,then injecting the formaldehyde into the stomach of rabbits for making the models of gastric noxious stimulation, the skin extravasation plots were observed and the skin referral area was found out.Moreover,the distribution regulation of primary neurons and sympathetic neurons were observed respectively by injecting HRP into the referral area and NY into the gastric mucosa respectively using neural retrograde tracing method.Results The pain referral area of rabbit was in the shoulder and scapular region.After injecting HRP into the referral area and NY into the gastric mucosa respectively,the C8- T8 spinal ganglion and sympathetic ganglion were superposed with each other.Conclusion The distribution characteristics of primary neurons in skin referral area and gastric mucosa are that spinal ganglions present segmental distribution and superposing with each other,moreover,sympathetic ganglions present diffused distribution and have no segmental distribution,which may be the neural basis of treating visceral pain by intracutaneous- injection drug.