Substance P and its receptor in CA3 area of hippocampus in multi- cerebral infarction rat
Abstract：Aim To observe changes of SP and SPR in CA3 area of rat hippocampus in multi- cerebral infarction(MCI) and influence of combination of nerve growth factor(NGF) and Svate- 3 on MCI and provide experimental basis for further exploration of intracellular mechanism in MCI and clinical treatment.Method 30 Wistar rats were randomly divided into normal control group,experiment control group and experiment group.Animal model of MCI ischemia was established by microemboli embolism blocking.Changes of SP and SPR in rat hippocampus CA3 area were observed with histochemical method combined with microgram analysis and effects of NGF,Svate- 3 on neurons in CA3 area of MCI hippocampus were compared.Results Mean positive gray values of SP and SPR in experiment control group were higher than those in normal control group[(202± 10) ,( 127± 7) and ( 168± 8) ,( 95± 9), P< 0.01〗 .Conclusion SP and SPR may participate into pathophysiological process of MCI,NGF and Svate- 3 can alleviate injury of neurons under ischemic condition and improve survival ability.
Keywords：nerve growth factorhippocampusbrain infarctionsubstance Preceptorsneurokinin- 1
Publication Date：2003-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 2438-2439 )