Correlation between vascular dementia and changes of acetylcholine and platelet activating factor
Abstract：Aim To observe the significance of dynamic changes of acetylcholine and platelet activating factor in pathogenic mechanism of vascular dementia. Methods 30 Wistar rats were randomly divided into model group (group A) and control group(group B). In model grouop,bilateral common carotid arteries were intermittently blocked with silk suture of 0 size for 10 minutes ,reperfused for 10 minutes.Common carotid artery was blocked for 3 times in total with 10 minutes of intervals.At the same time,2 ml of blood was withdrawn.In control group,bilateral common carotid arteries were only separated. Concentration of acetylcholie(Ach) and platelet activating factor(PAF) in rats, hippocampuses were measured with high performance thin- layer chromatography and colorimetric method.Results 2,3,5 day after operation , there was significant difference in the concentration of ACch(F=20.530,P< 0.05), no significant difference in PAF between the two groups(F=2.98,P >0.05). Conclusion The continuous decline of ACh concentration of hippocampuses may be one of the reasons for VaD occurrence and development; but PAF may participate mainly in the pathophysiological course in the early stage and have few effect in the later stage of cerebral ischemia.
Keywords：dementiaacetylcholieplatelet activating factor
Publication Date：2003-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 2270-2272 )