Relationship between the susceptibility to sporadic Alzheimer's disease and the gene frequency of leukocyte antigen
Abstract：Aim To investigate the relationship between the susceptibility to sporadic Alzheimer's disease(SAD) and the gene frequency of HLA- DR2,DRB1* 04 and DRB1* 09 and to reveal the pathogenesis of SAD from the point of view of molecular immunogenetics.Methods The gene frequency of HLA- DR2,DRB1* 04 and DRB1* 09 were detected separately by using sequence special primer- polymerase chain reaction(PCR- SSP) in 44 SAD patients and 45 healthy control subjects.Results The gene frequency of HLA- DR2 allele(28.4% ,OR=2.384,P< 0.05)was much higher in SAD patients than in normal subjects(17.8% ) while the gene frequency of HLA- DRB1* 04(5.7% vs 14.4% ,OR=0.313,P< 0.05)was much lower.There was no difference for the gene HLA- DRB1* 09 between the two groups.Conclusion HLA- DR2 allele may increase the risk of the onset of SAD while HLA- DRB1* 04 may play a protective role in the pathogenesis of SAD.There is no correlation between HLA- DRB1* 09 allele and the onset of SAD
Keywords：Alzheimer's diseasepolymerase chain reactionHLA- DR2 antigen
Publication Date：2003-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 2260-2261 )