Feasibility study of establishing more approaching clinically thrombosis by using model of deep veins of lower limb thrombus
Abstract：Aim To evaluate the feasibility of one simple method to establish model of venous thrombosis for studying the therapeutic effect of intracavitary ultrasonic therapy on venous thrombus of animal models.Methods The lower limbs of 20 dogs were divided randomly into the experimental group and the control group.The femoral veins of the experimental group were ligated at the close and distant end respectively to slower the flow of blood.The veins in control group were operated but not ligated.Then,the changes of the dogs' lower limbs were observed and the femoral veins were excised for pathological examinations and examined to investigate the condition of thrombis in the veins at the 1st,4th and 7th day respectively after operation.Results All the dog's lower limbs in the experimental group swelled and were lame slightly,the thrombus came forth in all the 6 veins by pathologic study at the 1st day after operation.And it was opposite in the control group.In addition,the swelling of all the dogs' lower limbs was aggravated and all the 14 femoral veins were filled with compact mixed thrombus at the 4th and 7th day after operation.And it was also opposite in the control group.Conclusion The method to establish models of venous thrombosis by the simple ligation of close and distant end of the femoral veins can make thrombosis more approaching clinical course of thrombosis and is satisfying.
Keywords：thrombosisdisease modelsfemoral veindog
Publication Date：2003-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 2001-2002 )