Dose-effect and time-effect of propofol on δ-band of quantitative pharmaco-EEG
Abstract：Aim The study is to investigate the effects of propofol on δ-band of quantitative pharmaco-electroencephalography(QPEEG) in the rabbits, determination of dose-effect and time-effect relationships.Methods One dose of propofol was injected to the rabbits.The EEG samples were obtained prior to and at regular intervals following the injection of propofol.The EEG activity was processed with the power spectral analysis.Results The percentage of δ-band power showed no significant changes in group of 2.5 mg/kg; The percentage of δ-band power were increased 1 folds higher, but did not reach significant level(P >0.05) in group 5 mg/kg.However, the changes in group 10 mg/kg was significant (r=0.68,0.84,0.93,0.94,P< 0.01,P< 0.05), and moreover it has parallelism with behavior alteration of the rabbit from 20 s to 5 min.A positive correlation of δ-band power and propofol dose was detected during 5 min(r=0.62- 0.95, P< 0.01).Couclusion With the increase of propofol dose,the percentage of power progressively increased at δ-band, it is suggested that the percentage of power at δ-band would be a effective mean of monitoring anesthesia depth.
Keywords：propofolanestheticsintravenouselectroen cephalography
Publication Date：2003-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1894-1896 )