Evoked potentials in type 2 diabetic patients and related factors

doi:10.3321/j.issn:1673-8225.2003.13.015

Abstract：Aim To study the relationship between the visual evoked potential(VEP),brain-stem auditory evoked potential(BAEP),somatosensory evoked potential(SEP),event-related potential(ERP) of type-2 diabetes mellitus(DM group) and their clinical parameters .Methods The Nicolet Viking TV type electromyography(EMG)/evoked potential machine was used for measuring VEP,BAEP,SEP and ERP of 30 type 2 DM patients and 30 normal people with similar age and sex .The relationship between the EP manifestations in DM group and their clinical parameters(including course of disease,blood sugar,plasma lipid,renal function and angiopathy) was analyzed with SPSS software parcel.Results In the DM group, abnormal VEP was found in 20 cases, BAEP in 18,MNSEP in 20 ,PTNSEP in 22, and ERP in 11.Compared with control group,the P100 latency of VEP,the latencies of waveⅠ and Ⅴ and the amplitude of waveⅤ as well as the interpeak latencies of each wave in BAEP, the latencies and wave amplitudes in N9 to P25/P38 of MNSEP and PTNSEP, the latency and amplitude of each wave of ERP were significantly increased (F=5.131- 45.213,t=2.695- 3.472,P< 0.05- 0.01) . Furthermore, the changes of latencies as well as the amplitudes of EP were closely related to the level of blood glucose and the concentration of the blood lipids and the renal function as well as vascular pathological changes.Conclusion The VEP,BAEP,SEP and ERP of DM patients are all abnormality in various extent,which parallel with course of disease.