Effects of Lessening scar burn ointment in a porcine model of burn wound healing
Abstract：Aim Lessening scar burn ointment(LSBO) is a Chinese traditional medicine for external use,it can improve the burn wound healing and has been applied in clinic.In this experiment,we investigated the effects of LSBO on burn wound healing,and explore the possible mechanism in burn wound healing.Methods 4 miniature pigs were used in this study.9 burn wounds,2.54 cm2 in area and depth II,on the back of each pig were made.A total of 36 burn wounds were divided into 3 groups as flollows:LSBO treated group,Vaseline treated group and untreated group of the wound surface.The therapeutic effects were evaluated by the burn areas,PCNA(proliferating cell nuclear antigen) immunohistochemical staining and the histologic changes.Results On 11th day after burn,the wound areas in LSBO treated group were minimized to (0.10± 0.03) cm2,much smaller than that of the Vaseline treated group[(0.81± 0.54) cm2,P< 0.05,t=- 3.22] and untreated group[(0.70± 0.21) cm2,P< 0.05,t=- 6.93].All the wounds in 3 groups showed excessive positive reaction examined with PCNA staining on 7th and 11th day after burn,respectively.Histological examination showed that granulation tissue and collagen fibril in LSBO treated group were richer than that of the other two groups on day 7 after burn.On day 11 after burn the wounds of LSBO treated group were nearly healed,and the wounds in the latter two groups did not close up yet.Conclusion Our present findings have significant implications that LSBO could promote healing of burn wound,dissolve the scar and improve the formation of fibrous tissue and epithelium.
Keywords：burnsswineminiaturepharmaceutical preparations
Publication Date：2003-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1642-1643 )