Expression of interleukin-8 in the condyle of temporomandibular joint after indirect trauma
Abstract：Aim In order to understand the roles of interleukin-8 (IL－ 8) in the pathogenesis of temporomandibular joint (TMJ) after indirect trauma.Methods A total of 25 healthy immature goats (15 males, 10 females), weighing between 15.0 and 20.0 kg,aging 6.0－ 8.0 months,were used in this study.All animals were divided into five subgroups (A, B, C, D, E) including five animals (2 females, 3 males) in each group at random.Trauma to the TMJ in 25 goats was achieved under an impact to the right and left mandibular angle with a self-made device.The goats of A,B,C,D groups were killed at 2 h, 7d,1 month and 3 months after impact respectively.The expression of interleukin-8 in the condyle of TMJ was observed by immunohistoch emical stainning.The normal TMJs of E group were used as controls.Results The positive expression of IL-8 was observed in the condyle of TMJ after indirect trauma.The stronger expression was observed in the destroyed area of condyle.Conclusion IL-8 may play an important role in the pathogenesis of TMJ after indirect trauma.
Keywords：temporomandibular jointwound and injuriesinterleukin-8
Publication Date：2003-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 1262-1263 )