The function of different collogens in hypertrophic scars

doi:10.3321/j.issn:1673-8225.2001.10.020

Abstract：Objective The aim of this study was toinvestigate the dynamic changes of collagen Ⅰ and Ⅲ in the formation of hypertrophic scar afterbum. Method The sirius red and polarizationmicroscopy was used to detected the collagen Ⅰ and Ⅲ fibers in scar tissues in vary periods. Radial immunology assay methods were used to evaluatethe contents of procollagen Ⅰ and Ⅲ in vary periodsin HS tissue. Result Collagen Ⅲ fiber is the main collagen in normalskin. There were no collagen fibers been found in granulation tissue. Collagen Ⅰ increased significantly in scar tissue 1 month after burn, increased much more in 3 months than in 1 month. The collagen were nearly thick collagen Iin HS tissue 1.5 year afterburn and only a little collagen Ⅲ were found. The RIA result showed that the ratio of procollagen Ⅰ/Ⅲ were increased gradually but the contents of collagen Ⅲ were much higher than normal skin. Conclusion In the process of HS forming after burn collagen Ⅰ increase and collagen Ⅲ decrease gradually and at last the collagens in HS were almost collagen Ⅰ. The zchanges of procollagcn can not reflect the changes of collagen fibers.