Fabrication of allogenic cartilage in predetermined shapes with tissue engineering technique
Abstract：Objective To investigate the feasibility of the formation of tissue engineered cartilage in predetermined shapes using polylycolic acid(PGA) as scaffold seeded with allogenic chondrocytes in immune animals. Method Chondroxytes were obtained from costa and articular cartilage of infant rabbits within one week. The cells were cultured in citro for 3～4 generations. Next, it was seeded onto PGA scaffolds previously predetermined tube-shaped and slice-shaped and soaked with poly-L-lysine. Finally, the neocartilages were evaluated grossly and histologically. Result The matrix like cobweb was observed about 1 week after seeding chondrocytes onto PGA. 6 weeks of implantation,the near-mature neocartilage had regenerated in allogragt animals. Conclusion It is possible to form new cartilage in allograft animals with immunity by seeding allogenic chondrocytes onto PGA scaffolds in predetermined shape.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 38-39 )