Study on calcium phosphate cement/bone morphogenic protein composite in repairing bone defects
Abstract：Objective To study the change of ultrastructure and osteogenesis character of calcium phosphate cement/bone morphogenic protein(CPC/BMP) composite in repairing segmental bone defects. Method A new bone grafting material of CPC/BMP composite and CPC were prepared, a 15 mm bone defect experimental model in radius of rabbits were made, the CPC/BMP or CPC were implanted into the defects. The osteogenesis of the bone in the defect area and the change of material ultrastructure were observed by scanning electron microscope.X-ray, energy dispersion analysis X-ray and bone density meter. Result CPC/BMP composite was capable of healing the defect in large part by 24 weeks, ultrastructure changed a lot and part of the material was absorbed. The amount of new bone in CPC group was distinctnesslittle than that of in CPC/BMP group. Couclusion The CPC/BMP composite is believed to be a new bone geafting material in dealing with segmental bone defect.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 32-33 )