The changes and it’ s implication of extracellular adenosine after exprimental spinal cord Injury
Abstract：To explore the role of adenosine in secondary spinal cord injury.Method A ventral compression injury model of T13 spinal cord was used, and the extracellular fluids were collected consecutively every 20 min after injury by using microdialysis. The adenosine in the samples was analyzed by using a high pressure liquid chromatography (HPLC) system with u.v. detection.Result Conclusion The results showed a significant increase of adenosine immediately after spinal cord injury. The concentration of adenosine reached the peak at 1h after injury and dropped down to the basal level. There was positive revelance between the increasing of adenosine and the severity of SCI.Conclusion The present finding suggests that adenosie could be involved in the pathological progress of secondary spinal cord injury and might play a protective role in SCI.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)